SURG-05. MRI-GUIDED FOCUSED ULTRASOUND BLOOD-BRAIN BARRIER DISRUPTION INCREASES DRUG DELIVERY AND EFFICACY IN AN ORTHOTOPIC DIPG MODEL

Diffuse intrinsic pontine glioma is the most common and deadliest pediatric brainstem tumor and is difficult to treat with chemotherapy in part due to the blood-brain barrier (BBB). Focused ultrasound (FUS) and microbubbles (MBs) have been shown to cause BBB disruption (BBBD), allowing larger chemot...

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Detalles Bibliográficos
Autores principales: Martinez, Payton, Nault, Genna, Steiner, Jenna, Wempe, Michael, Pierce, Angela, Brunt, Breaunna, Slade, Mathew, Mongin, Andrew, Song, Jane, Song, Kang-Ho, Ellens, Nicholas, Serkova, Natalie, Green, Adam, Borden, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Neurosurgery/Focused Ultrasound/Drug Delivery - SURG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260190/
http://dx.doi.org/10.1093/neuonc/noad073.281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260190/
http://dx.doi.org/10.1093/neuonc/noad073.281

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