HGG-26. GENOMIC AND IMMUNE ANALYSIS OF PRIMARY REPLICATION-REPAIR DEFICIENT (RRD) GLIOMAS REVEALS THREE SUBGROUPS WITH DISTINCT DRIVERS AND RESPONSE TO IMMUNOTHERAPY: AN IRRDC REPORT

BACKGROUND: Replication-repair deficiency (RRD) caused by germline/somatic defects in mismatch repair (MMRD) and/or polymerase-proofreading genes (PPD) drives 5-10% of gliomas in children, adolescents, and young adults (CAYA). Although RRD-gliomas harbour high mutation-burden (TMB), the basis of the...

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Detalles Bibliográficos
Autores principales: Fernandez, Nicholas R, Das, Anirban, Levine, Adrian, Negm, Logine, Nobre, Liana, Bianchi, Vanessa, Stengs, Lucie, Chung, Jiil, Nunes, Nuno M, Edwards, Melissa, Bouffet, Eric, Hawkins, Cynthia, Tabori, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260197/
http://dx.doi.org/10.1093/neuonc/noad073.175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260197/
http://dx.doi.org/10.1093/neuonc/noad073.175

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