α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis

Metabolic reprogramming is a hallmark of human malignancies. Dysregulation of glutamine metabolism is essential for tumorigenesis, microenvironment remodeling, and therapeutic resistance. Based on the untargeted metabolomics sequencing, we identified that the glutamine metabolic pathway was up-regul...

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Detalles Bibliográficos
Autores principales: Cai, Yiqing, Lv, Liemei, Lu, Tiange, Ding, Mengfei, Yu, Zhuoya, Chen, Xiaomin, Zhou, Xiangxiang, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260963/
https://www.ncbi.nlm.nih.gov/pubmed/37308557
http://dx.doi.org/10.1038/s41420-023-01475-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260963/
https://www.ncbi.nlm.nih.gov/pubmed/37308557
http://dx.doi.org/10.1038/s41420-023-01475-1

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