A biscarbene gold(I)-NHC-complex overcomes cisplatin-resistance in A2780 and W1 ovarian cancer cells highlighting pERK as regulator of apoptosis

PURPOSE: Cisplatin resistance is the major obstacle in the clinical treatment of ovarian cancer patients. Molecular mechanisms of cisplatin resistance are multifaceted. Gold(I)-compounds, i.e. N-heterocyclic carbene-gold(I)-complexes (NHC-Au(I)) has been regarded as promising cytotoxic drug candidat...

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Detalles Bibliográficos
Autores principales: König, Philipp, Zhulenko, Roman, Suparman, Eloy, Hoffmeister, Henrik, Bückreiß, Nico, Ott, Ingo, Bendas, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261188/
https://www.ncbi.nlm.nih.gov/pubmed/37272932
http://dx.doi.org/10.1007/s00280-023-04548-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261188/
https://www.ncbi.nlm.nih.gov/pubmed/37272932
http://dx.doi.org/10.1007/s00280-023-04548-1

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