Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies

The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells’ HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers t...

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Detalles Bibliográficos
Autores principales: Fox, Bernard A., Urba, Walter J., Jensen, Shawn M., Page, David B., Curti, Brendan D., Sanborn, Rachel E., Leidner, Rom S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
CCR Translations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261915/
https://www.ncbi.nlm.nih.gov/pubmed/37040070
http://dx.doi.org/10.1158/1078-0432.CCR-23-0422
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author Fox, Bernard A.
Urba, Walter J.
Jensen, Shawn M.
Page, David B.
Curti, Brendan D.
Sanborn, Rachel E.
Leidner, Rom S.
author_facet Fox, Bernard A.
Urba, Walter J.
Jensen, Shawn M.
Page, David B.
Curti, Brendan D.
Sanborn, Rachel E.
Leidner, Rom S.
author_sort Fox, Bernard A.
collection PubMed
description The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells’ HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens. See related article by Lozano-Rabella et al., p. 2250
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spelling pubmed-102619152023-06-15 Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies Fox, Bernard A. Urba, Walter J. Jensen, Shawn M. Page, David B. Curti, Brendan D. Sanborn, Rachel E. Leidner, Rom S. Clin Cancer Res CCR Translations The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells’ HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens. See related article by Lozano-Rabella et al., p. 2250 American Association for Cancer Research 2023-06-13 2023-04-11 /pmc/articles/PMC10261915/ /pubmed/37040070 http://dx.doi.org/10.1158/1078-0432.CCR-23-0422 Text en ©2023 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
spellingShingle CCR Translations
Fox, Bernard A.
Urba, Walter J.
Jensen, Shawn M.
Page, David B.
Curti, Brendan D.
Sanborn, Rachel E.
Leidner, Rom S.
Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies
title Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies
title_full Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies
title_fullStr Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies
title_full_unstemmed Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies
title_short Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies
title_sort cancer's dark matter: lighting the abyss unveils universe of new therapies
topic CCR Translations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261915/
https://www.ncbi.nlm.nih.gov/pubmed/37040070
http://dx.doi.org/10.1158/1078-0432.CCR-23-0422
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