Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications

In a recent issue of Science, Zecha et al.(1) present decryptM, an approach aimed at defining the mechanisms of action of anti-cancer therapeutics through systems-level analysis of protein post-translational modifications (PTMs). By using a broad range of concentrations, decryptM generates drug resp...

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Detalles Bibliográficos
Autores principales: Herbst, Sophie A., White, Forest M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261922/
https://www.ncbi.nlm.nih.gov/pubmed/37323574
http://dx.doi.org/10.1016/j.crmeth.2023.100483
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author Herbst, Sophie A.
White, Forest M.
author_facet Herbst, Sophie A.
White, Forest M.
author_sort Herbst, Sophie A.
collection PubMed
description In a recent issue of Science, Zecha et al.(1) present decryptM, an approach aimed at defining the mechanisms of action of anti-cancer therapeutics through systems-level analysis of protein post-translational modifications (PTMs). By using a broad range of concentrations, decryptM generates drug response curves for each detected PTM, enabling identification of drug effects at different therapeutic doses.
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spelling pubmed-102619222023-06-15 Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications Herbst, Sophie A. White, Forest M. Cell Rep Methods Spotlight In a recent issue of Science, Zecha et al.(1) present decryptM, an approach aimed at defining the mechanisms of action of anti-cancer therapeutics through systems-level analysis of protein post-translational modifications (PTMs). By using a broad range of concentrations, decryptM generates drug response curves for each detected PTM, enabling identification of drug effects at different therapeutic doses. Elsevier 2023-05-22 /pmc/articles/PMC10261922/ /pubmed/37323574 http://dx.doi.org/10.1016/j.crmeth.2023.100483 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Spotlight
Herbst, Sophie A.
White, Forest M.
Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications
title Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications
title_full Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications
title_fullStr Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications
title_full_unstemmed Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications
title_short Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications
title_sort decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261922/
https://www.ncbi.nlm.nih.gov/pubmed/37323574
http://dx.doi.org/10.1016/j.crmeth.2023.100483
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