Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags

Hexanucleotide repeat expansions in the C9orf72 gene are the most prevalent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Transcripts of the expansions are translated into toxic dipeptide repeat (DPR) proteins. Most preclinical studies in cell and animal models have use...

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Detalles Bibliográficos
Autores principales: Morón-Oset, Javier, Fischer, Lilly KS, Carcolé, Mireia, Giblin, Ashling, Zhang, Pingze, Isaacs, Adrian M, Grönke, Sebastian, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262077/
https://www.ncbi.nlm.nih.gov/pubmed/37308278
http://dx.doi.org/10.26508/lsa.202201739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262077/
https://www.ncbi.nlm.nih.gov/pubmed/37308278
http://dx.doi.org/10.26508/lsa.202201739

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