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Using modified intention-to-treat as a principal stratum estimator for failure to initiate treatment

BACKGROUND: A common intercurrent event affecting many trials is when some participants do not begin their assigned treatment. For example, in a double-blind drug trial, some participants may not receive any dose of study medication. Many trials use a ‘modified intention-to-treat’ approach, whereby...

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Detalles Bibliográficos
Autores principales: Kahan, Brennan C, White, Ian R, Edwards, Mark, Harhay, Michael O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262320/
https://www.ncbi.nlm.nih.gov/pubmed/36916466
http://dx.doi.org/10.1177/17407745231160074