Pharmacological inhibition of human EZH2 can influence a regenerative β-like cell capacity with in vitro insulin release in pancreatic ductal cells

BACKGROUND: Therapeutic replacement of pancreatic endocrine β-cells is key to improving hyperglycaemia caused by insulin-dependent diabetes . Whilst the pool of ductal progenitors, which give rise to the endocrine cells, are active during development, neogenesis of islets is repressed in the human a...

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Detalles Bibliográficos
Autores principales: Naina Marikar, Safiya, Al-Hasani, Keith, Khurana, Ishant, Kaipananickal, Harikrishnan, Okabe, Jun, Maxwell, Scott, El-Osta, Assam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262441/
https://www.ncbi.nlm.nih.gov/pubmed/37309004
http://dx.doi.org/10.1186/s13148-023-01491-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262441/
https://www.ncbi.nlm.nih.gov/pubmed/37309004
http://dx.doi.org/10.1186/s13148-023-01491-z

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