Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment

MDH1 and MDH2 enzymes play an important role in the survival of lung cancer. In this study, a novel series of dual MDH1/2 inhibitors for lung cancer was rationally designed and synthesized, and their SAR was carefully investigated. Among the tested compounds, compound 50 containing a piperidine ring...

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Detalles Bibliográficos
Autores principales: Godesi, Sreenivasulu, Han, Jeong-Ran, Kim, Jang-Keun, Kwak, Dong-Ik, Lee, Joohan, Nada, Hossam, Kim, Minkyoung, Yang, Hyun-A, Im, Joo-Young, Ban, Hyun Seung, Lee, Chang Hoon, Choi, Yongseok, Won, Misun, Lee, Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263210/
https://www.ncbi.nlm.nih.gov/pubmed/37242466
http://dx.doi.org/10.3390/ph16050683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263210/
https://www.ncbi.nlm.nih.gov/pubmed/37242466
http://dx.doi.org/10.3390/ph16050683

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