The angiotensin receptor neprilysin inhibitor LCZ696 attenuates renal fibrosis via ASK1/JNK/p38 MAPK-mediated apoptosis in unilateral ureteral obstruction

The angiotensin receptor neprilysin inhibitor LCZ696 affords superior cardioprotection and renoprotection compared with renin-angiotensin blockade monotherapy, but the underlying mechanisms remain elusive. Herein, we evaluated whether LCZ696 attenuates renal fibrosis by inhibiting ASK1/JNK/p38 mitog...

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Detalles Bibliográficos
Autores principales: Ding, Jun, Cui, Sheng, Li, Song Yu, Cui, Lin Yan, Nan, Qi Yan, Lin, Xue Jing, Xuan, Mei Ying, Jin, Jian, Piao, Shang Guo, Jiang, Yu Ji, Zheng, Hai Lan, Jin, Ji Zhe, Chung, Byung Ha, Yang, Chul Woo, Cui, Jing Hao, Li, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263316/
https://www.ncbi.nlm.nih.gov/pubmed/37310976
http://dx.doi.org/10.1371/journal.pone.0286903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263316/
https://www.ncbi.nlm.nih.gov/pubmed/37310976
http://dx.doi.org/10.1371/journal.pone.0286903

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