Cargando…

The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

BACKGROUND: The long co-evolution of Homo sapiens and Plasmodium falciparum has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the Dantu blood group antigen, which is associated with 74% protection against s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kariuki, Silvia N, Macharia, Alexander W, Makale, Johnstone, Nyamu, Wilfred, Hoffman, Stephen L, Kapulu, Melissa C, Bejon, Philip, Rayner, Julian C, Williams, Thomas N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264070/ https://www.ncbi.nlm.nih.gov/pubmed/37310872 http://dx.doi.org/10.7554/eLife.83874

Ejemplares similares

Red blood cell tension protects against severe malaria in the Dantu blood group
por: Kariuki, Silvia N., et al.
Publicado: (2020)

Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research
por: Mohring, Franziska, et al.
Publicado: (2019)

The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria
por: Uyoga, S., et al.
Publicado: (2022)

Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort
por: Muthui, Michelle K., et al.
Publicado: (2019)

Deliberately infecting healthy volunteers with malaria parasites: Perceptions and experiences of participants and other stakeholders in a Kenyan‐based malaria infection study
por: Jao, Irene, et al.
Publicado: (2020)

The genome of an intranuclear parasite, Paramicrosporidium saccamoebae, reveals alternative adaptations to obligate intracellular parasitism
por: Quandt, C Alisha, et al.
Publicado: (2017)

Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium falciparum malaria parasite growth in the context of pre-existing immunity
por: Kapulu, Melissa C., et al.
Publicado: (2019)

Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila
por: Elya, Carolyn, et al.
Publicado: (2023)

Hepcidin regulation in Kenyan children with severe malaria and non-typhoidal Salmonella bacteremia
por: Abuga, Kelvin M., et al.
Publicado: (2021)

Ethical considerations in Controlled Human Malaria Infection studies in low resource settings: Experiences and perceptions of study participants in a malaria Challenge study in Kenya
por: Njue, Maureen, et al.
Publicado: (2018)

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
por: Cowell, Annie N., et al.
Publicado: (2018)

Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria
por: Georgiadou, Athina, et al.
Publicado: (2022)

BIRC6 modifies risk of invasive bacterial infection in Kenyan children
por: Gilchrist, James J, et al.
Publicado: (2022)

Immune Responses to Gametocyte Antigens in a Malaria Endemic Population—The African falciparum Context: A Systematic Review and Meta-Analysis
por: Muthui, Michelle K., et al.
Publicado: (2019)

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum
por: Lu, Xueqing Maggie, et al.
Publicado: (2017)

Corrigendum: Immune Responses to Gametocyte Antigens in a Malaria Endemic Population—The African falciparum Context: A Systematic Review and Meta-Analysis
por: Muthui, Michelle K., et al.
Publicado: (2020)

Rare Alleles and Signatures of Selection on the Immunodominant Domains of Pfs230 and Pfs48/45 in Malaria Parasites From Western Kenya
por: Ochwedo, Kevin O., et al.
Publicado: (2022)

PhenoPlasm: a database of disruption phenotypes for malaria parasite genes
por: Sanderson, Theo, et al.
Publicado: (2017)

Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement
por: Hoermann, Astrid, et al.
Publicado: (2021)

Deep Learning Methods in Predicting Gene Expression Levels for the Malaria Parasite
por: Tran, Tuan, et al.
Publicado: (2021)

Genotype by environment interaction and heteroscedasticity influence the expression of parasite resistance in Katahdin sheep
por: Arisman, Brian C, et al.
Publicado: (2023)

Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer
por: Koussounadis, A, et al.
Publicado: (2014)

Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
por: Weber, F, et al.
Publicado: (2005)

PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells
por: Tiffin, N, et al.
Publicado: (2003)

Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda
por: Stevenson, Anne, et al.
Publicado: (2019)

Comparison between methods for measuring fecal egg count and estimating genetic parameters for gastrointestinal parasite resistance traits in sheep
por: Boareki, Mohammed N, et al.
Publicado: (2021)

Ethical considerations around volunteer payments in a malaria human infection study in Kenya: an embedded empirical ethics study
por: Chi, Primus Che, et al.
Publicado: (2022)

Clustering climate and management practices to define environmental challenges affecting gastrointestinal parasitism in Katahdin sheep
por: Arisman, Brian C, et al.
Publicado: (2023)

Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus
por: Tomlinson, V A L, et al.
Publicado: (2007)

Plasma Plasmodium falciparum Histidine-rich Protein 2 Concentrations in Children With Malaria Infections of Differing Severity in Kilifi, Kenya
por: Uyoga, Sophie, et al.
Publicado: (2020)

High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma
por: Cairney, C J, et al.
Publicado: (2008)

Genetic analysis of Boletus edulis suggests that intra-specific competition may reduce local genetic diversity as a woodland ages
por: Hoffman, J. I., et al.
Publicado: (2020)

When to break the news and whose responsibility is it? A cross-sectional qualitative study of health professionals’ views regarding disclosure of BRCA genetic cancer risk
por: Young, Alison Luk, et al.
Publicado: (2020)

Anti-angiogenic action of hyperthermia by suppressing gene expression and production of tumour-derived vascular endothelial growth factor in vivo and in vitro
por: Sawaji, Y, et al.
Publicado: (2002)

Are microRNAs located in genomic regions associated with cancer?
por: Lamy, P, et al.
Publicado: (2006)

Delivering genome sequencing in clinical practice: an interview study with healthcare professionals involved in the 100 000 Genomes Project
por: Sanderson, Saskia C, et al.
Publicado: (2019)

Malignant germ cell tumours of childhood: new associations of genomic imbalance
por: Palmer, R D, et al.
Publicado: (2007)

Lipoprotein lipase is frequently overexpressed or translocated in cervical squamous cell carcinoma and promotes invasiveness through the non-catalytic C terminus
por: Carter, S A, et al.
Publicado: (2012)

Detecting Malaria Hotspots: A Comparison of Rapid Diagnostic Test, Microscopy, and Polymerase Chain Reaction
por: Mogeni, Polycarp, et al.
Publicado: (2017)

Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
por: Wani, K M Y, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_q2j5rdfpvgtn0k2jt3b9f5tgs8