PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression

BACKGROUND: Type 2 diabetes is characterized by reduced insulin sensitivity, elevated blood metabolites, and reduced mitochondrial metabolism with reduced expression of genes governing metabolism such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). PGC-1α regulates...

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Detalles Bibliográficos
Autores principales: Rivera, Caroline N., Hinkle, Jason S., Watne, Rachel M., Macgowan, Trent C., Wommack, Andrew J., Vaughan, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264138/
https://www.ncbi.nlm.nih.gov/pubmed/37325367
http://dx.doi.org/10.1155/2023/4779199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264138/
https://www.ncbi.nlm.nih.gov/pubmed/37325367
http://dx.doi.org/10.1155/2023/4779199

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