Cargando…

PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression

BACKGROUND: Type 2 diabetes is characterized by reduced insulin sensitivity, elevated blood metabolites, and reduced mitochondrial metabolism with reduced expression of genes governing metabolism such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). PGC-1α regulates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rivera, Caroline N., Hinkle, Jason S., Watne, Rachel M., Macgowan, Trent C., Wommack, Andrew J., Vaughan, Roger A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264138/ https://www.ncbi.nlm.nih.gov/pubmed/37325367 http://dx.doi.org/10.1155/2023/4779199

Ejemplares similares

The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus
por: Zhou, Jun, et al.
Publicado: (2020)

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
por: Zhou, Meiyi, et al.
Publicado: (2019)

BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice
por: Wang, Ji, et al.
Publicado: (2019)

Dataset reporting BCKDK interference in a BCAA-catabolism restricted environment
por: Bravo-Alonso, I., et al.
Publicado: (2016)

A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice
por: Chen, Wei, et al.
Publicado: (2015)

BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer
por: Xue, Peipei, et al.
Publicado: (2017)

Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer
por: Tian, Qin, et al.
Publicado: (2020)

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth
por: Lei, Ming-Zhu, et al.
Publicado: (2020)

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model
por: Voronova, Veronika, et al.
Publicado: (2022)

The PPARδ Ligand GW501516 Reduces Growth but Not Apoptosis in Mouse Inner Medullary Collecting Duct Cells
por: Clark, Jordan, et al.
Publicado: (2009)

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44
por: Yoneshiro, Takeshi, et al.
Publicado: (2019)

Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
por: Ericksen, Russell E., et al.
Publicado: (2019)

A cell-autonomous mechanism regulates BCAA catabolism in white adipocytes and systemic metabolic balance
por: Aguillard, Ashley M., et al.
Publicado: (2023)

Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
por: Defaux, Antoinette, et al.
Publicado: (2009)

A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents
por: Moran-Ramos, Sofia, et al.
Publicado: (2021)

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes
por: Vanweert, Froukje, et al.
Publicado: (2022)

Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia
por: Hattori, Ayuna, et al.
Publicado: (2017)

Elevated BCAA Suppresses the Development and Metastasis of Breast Cancer
por: Chi, Rui, et al.
Publicado: (2022)

PPARβ/δ Agonist GW501516 Inhibits Tumorigenicity of Undifferentiated Nasopharyngeal Carcinoma in C666-1 Cells by Promoting Apoptosis
por: Ji, Yangyang, et al.
Publicado: (2018)

PPARδ Agonist GW501516 Suppresses the TGF-β-Induced Profibrotic Response of Human Bronchial Fibroblasts from Asthmatic Patients
por: Paw, Milena, et al.
Publicado: (2023)

GW501516, a PPAR-BETA/DELTA agonist, improves inflammatory pathways in the kidney of high-fructose fed mice
por: Magliano, D'Angelo Carlo, et al.
Publicado: (2015)

Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway
por: Li, Zhujun, et al.
Publicado: (2023)

PPARδ Agonist GW501516 Inhibits PDGF-Stimulated Pulmonary Arterial Smooth Muscle Cell Function Related to Pathological Vascular Remodeling
por: Liu, Guangjie, et al.
Publicado: (2013)

Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma
por: Kitagawa, Akihiro, et al.
Publicado: (2023)

Effects of Long-Term Physical Activity and BCAA Availability on the Subcellular Associations between Intramyocellular Lipids, Perilipins and PGC-1α
por: Fachada, Vasco, et al.
Publicado: (2023)

Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC
por: Xue, Meiting, et al.
Publicado: (2023)

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
por: Kostadinova, Radina, et al.
Publicado: (2012)

The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos
por: Idrees, Muhammad, et al.
Publicado: (2019)

Consumption of a Branched-Chain Amino Acid (BCAA) during Days 2–10 of Pregnancy Causes Abnormal Fetal and Placental Growth: Implications for BCAA Supplementation in Humans
por: To, Chiu Yuen, et al.
Publicado: (2020)

Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicks
por: Tsuneyoshi, Yousuke, et al.
Publicado: (2007)

The Effect of BCAA and ISO-WHEY Oral Nutritional Supplements on Dialysis Adequacy
por: Afaghi, Effat, et al.
Publicado: (2016)

Obesity, exercise training, and BCAA supplementation: All that glitters (may not be) gold
por: Carter, Stephen J., et al.
Publicado: (2022)

Serum Branch Chain Amino Acids (BCAAs) Are Elevated Due to Decreased Catabolism in Patients With Ketosis-Prone Diabetes at the Time of Presentation With DKA
por: Hsu, Jean Wei, et al.
Publicado: (2021)

The Selective LAT1 Inhibitor JPH203 Enhances Mitochondrial Metabolism and Content in Insulin-Sensitive and Insulin-Resistant C2C12 Myotubes
por: Rivera, Caroline N., et al.
Publicado: (2023)

Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
por: Lu, Qing-Bo, et al.
Publicado: (2023)

The Impaired Function of Macrophages Induced by Strenuous Exercise Could Not Be Ameliorated by BCAA Supplementation
por: Xiao, Weihua, et al.
Publicado: (2015)

Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance
por: Gojda, Jan, et al.
Publicado: (2021)

GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice
por: Yang, Xu, et al.
Publicado: (2011)

PPARβ/δ Agonist GW501516 Inhibits Tumorigenesis and Promotes Apoptosis of the Undifferentiated Nasopharyngeal Carcinoma C666-1 Cells by Regulating miR-206
por: Gu, Linglan, et al.
Publicado: (2019)

Two randomized controlled studies comparing the nutritional benefits of branched-chain amino acid (BCAA) granules and a BCAA-enriched nutrient mixture for patients with esophageal varices after endoscopic treatment
por: Sakai, Yoshiyuki, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_g3lovkem13m71r9otqqvgih3d9