Combining virtual screening with cis-/trans-cleavage enzymatic assays effectively reveals broad-spectrum inhibitors that target the main proteases of SARS-CoV-2 and MERS-CoV

The main protease (M(pro)) of SARS-CoV-2 is essential for viral replication, which suggests that the M(pro) is a critical target in the development of small molecules to treat COVID-19. This study used an in-silico prediction approach to investigate the complex structure of SARS-CoV-2 M(pro) in comp...

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Detalles Bibliográficos
Autores principales: Chang, Yu-Jen, Le, Uyen Nguyen Phuong, Liu, Jia-Jun, Li, Sin-Rong, Chao, Shao-Ting, Lai, Hsueh-Chou, Lin, Yu-Feng, Hsu, Kai-Cheng, Lu, Chih-Hao, Lin, Cheng-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264167/
https://www.ncbi.nlm.nih.gov/pubmed/37321487
http://dx.doi.org/10.1016/j.antiviral.2023.105653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264167/
https://www.ncbi.nlm.nih.gov/pubmed/37321487
http://dx.doi.org/10.1016/j.antiviral.2023.105653

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