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Thermodynamic Evolution of a Metamorphic Protein: A Theoretical-Computational Study of Human Lymphotactin

Metamorphic, or fold-switching, proteins feature different folds that are physiologically relevant. The human chemokine XCL1 (or Lymphotactin) is a metamorphic protein that features two native states, an [Formula: see text] and an all[Formula: see text] fold, which have similar stability at physiolo...

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Detalles Bibliográficos
Autores principales: Zanetti-Polzi, Laura, Daidone, Isabella, Iacobucci, Claudio, Amadei, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264484/
https://www.ncbi.nlm.nih.gov/pubmed/37233895
http://dx.doi.org/10.1007/s10930-023-10123-7