Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo

Introduction: The ligand-activated transcription factors, nuclear hormone receptors (NHRs), remain unexplored in hematological malignancies except for retinoic acid receptor alpha (RARA). Methods: Here we profiled the expression of various NHRs and their coregulators in Chronic myeloid leukemia (CML...

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Detalles Bibliográficos
Autores principales: Rajamani, Bharathi M., Illangeswaran, Raveen Stephen Stallon, Benjamin, Esther Sathya Bama, Balakrishnan, Balaji, Jebanesan, Daniel Zechariah Paul, Das, Saswati, Pai, Aswin Anand, Vidhyadharan, Rakhi Thalayattu, Mohan, Ajith, Karathedath, Sreeja, Abraham, Aby, Mathews, Vikram, Velayudhan, Shaji R., Balasubramanian, Poonkuzhali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264673/
https://www.ncbi.nlm.nih.gov/pubmed/37324449
http://dx.doi.org/10.3389/fphar.2023.1187066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264673/
https://www.ncbi.nlm.nih.gov/pubmed/37324449
http://dx.doi.org/10.3389/fphar.2023.1187066

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