Cargando…

Investigating cell-specific effects of FMRP deficiency on spiny projection neurons in a mouse model of Fragile X syndrome

INTRODUCTION: Fragile X syndrome (FXS), resulting from a mutation in the Fmr1 gene, is the most common monogenic cause of autism and inherited intellectual disability. Fmr1 encodes the Fragile X Messenger Ribonucleoprotein (FMRP), and its absence leads to cognitive, emotional, and social deficits co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giua, Gabriele, Lassalle, Olivier, Makrini-Maleville, Leila, Valjent, Emmanuel, Chavis, Pascale, Manzoni, Olivier J. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264852/ https://www.ncbi.nlm.nih.gov/pubmed/37323585 http://dx.doi.org/10.3389/fncel.2023.1146647

Ejemplares similares

Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala
por: Guily, Pauline, et al.
Publicado: (2022)

Detection and Quantification of the Fragile X Mental Retardation Protein 1 (FMRP)
por: LaFauci, Giuseppe, et al.
Publicado: (2016)

Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons
por: Graef, John D., et al.
Publicado: (2020)

Functional and structural deficits at accumbens synapses in a mouse model of Fragile X
por: Neuhofer, Daniela, et al.
Publicado: (2015)

Fragile phagocytes: FMRP positively regulates engulfment activity
por: Logan, Mary A.
Publicado: (2017)

Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies
por: Banerjee, Anwesha, et al.
Publicado: (2018)

Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP
por: Majumder, Pritha, et al.
Publicado: (2016)

Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome
por: Life, Benjamin, et al.
Publicado: (2023)

Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells
por: Medrano, Mireia, et al.
Publicado: (2023)

FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome
por: Zhan, Xiaoqin, et al.
Publicado: (2020)

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome
por: Jung, Kwang-Mook, et al.
Publicado: (2012)

Subcellular Fractionation and Localization Studies Reveal a Direct Interaction of the Fragile X Mental Retardation Protein (FMRP) with Nucleolin
por: Taha, Mohamed S., et al.
Publicado: (2014)

A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function
por: Okray, Zeynep, et al.
Publicado: (2015)

Single-Nucleotide Mutations in FMR1 Reveal Novel Functions and Regulatory Mechanisms of the Fragile X Syndrome Protein FMRP
por: Suhl, Joshua A., et al.
Publicado: (2015)

Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome
por: Russo, Alexandra, et al.
Publicado: (2019)

Altered inflammatory response in FMRP-deficient microglia
por: Parrott, Jennifer M., et al.
Publicado: (2021)

Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome
por: Yang, Chaojuan, et al.
Publicado: (2021)

The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum
por: Maurin, Thomas, et al.
Publicado: (2015)

Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs
por: Brighi, Carlo, et al.
Publicado: (2021)

A noncanonical RNA-binding domain of the fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes
por: Scarpitti, MaKenzie R., et al.
Publicado: (2022)

FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin–proteasome system
por: Shimizu, Hideo, et al.
Publicado: (2023)

Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits
por: Jiang, Yiru, et al.
Publicado: (2022)

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner
por: Iezzi, Daniela, et al.
Publicado: (2022)

An “Omic” Overview of Fragile X Syndrome
por: Dionne, Olivier, et al.
Publicado: (2021)

The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology
por: Huebschman, Jessica L., et al.
Publicado: (2020)

Reelin-Haploinsufficiency Disrupts the Developmental Trajectory of the E/I Balance in the Prefrontal Cortex
por: Bouamrane, Lamine, et al.
Publicado: (2017)

The feasibility and utility of hair follicle sampling to measure FMRP and FMR1 mRNA in children with or without fragile X syndrome: a pilot study
por: Jalnapurkar, Isha, et al.
Publicado: (2022)

Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens
por: Gangarossa, Giuseppe, et al.
Publicado: (2013)

Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP
por: Bartley, Christopher M., et al.
Publicado: (2016)

Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model
por: Ceolin, Laura, et al.
Publicado: (2017)

Reelin Secreted by GABAergic Neurons Regulates Glutamate Receptor Homeostasis
por: Campo, Cecilia Gonzalez, et al.
Publicado: (2009)

Striatal Medium-Sized Spiny Neurons: Identification by Nuclear Staining and Study of Neuronal Subpopulations in BAC Transgenic Mice
por: Matamales, Miriam, et al.
Publicado: (2009)

Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex
por: lezzi, Daniela, et al.
Publicado: (2023)

Multivariate synaptic and behavioral profiling reveals new developmental endophenotypes in the prefrontal cortex
por: Iafrati, Jillian, et al.
Publicado: (2016)

Deficient Sleep in Mouse Models of Fragile X Syndrome
por: Saré, R. Michelle, et al.
Publicado: (2017)

FMRP: a triple threat to PSD-95
por: Westmark, Cara J.
Publicado: (2013)

FMRP: a new chapter with chromatin
por: He, Qingzhong, et al.
Publicado: (2014)

Cellular localization of the FMRP in rat retina
por: Zhang, Ping-Ping, et al.
Publicado: (2020)

FMRP differentially regulates BK channels
por: Short, Ben
Publicado: (2020)

Fragile X syndrome and fragile X-associated disorders
por: Rajaratnam, Akash, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_il51bv3eg45ce22u7ut2j51o6b