Developing a mechanistic understanding of the nonlinear pharmacokinetics of letermovir and prospective drug interaction with everolimus using physiological‐based pharmacokinetic modeling

Letermovir is approved for use in cytomegalovirus‐seropositive hematopoietic stem cell transplant recipients and is investigated in other transplant settings. Nonlinear pharmacokinetics (PKs) were observed in clinical studies after intravenous and oral dosing across a wide dose range, including the...

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Detalles Bibliográficos
Autores principales: Menzel, Karsten, Kuo, Yuhsin, Chen, Dapeng, Hartmann, Georgy, Wang, Ying‐Hong, Cho, Carolyn R., McCrea, Jacqueline B., Asari, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264951/
https://www.ncbi.nlm.nih.gov/pubmed/37085998
http://dx.doi.org/10.1111/cts.13509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264951/
https://www.ncbi.nlm.nih.gov/pubmed/37085998
http://dx.doi.org/10.1111/cts.13509

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