Develop a Compact RNA Base Editor by Fusing ADAR with Engineered EcCas6e

Catalytically inactive CRISPR‐Cas13 (dCas13)‐based base editors can achieve the conversion of adenine‐to‐inosine (A‐to‐I) or cytidine‐to‐uridine (C‐to‐U) at the RNA level, however, the large size of dCas13 protein limits its in vivo applications. Here, a compact and efficient RNA base editor (ceRBE)...

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Detalles Bibliográficos
Autores principales: Wang, Xing, Zhang, Renxia, Yang, Dong, Li, Guoling, Fan, Zhanqing, Du, Hongting, Wang, Zikang, Liu, Yuanhua, Lin, Jiajia, Wu, Xiaoqing, Shi, Linyu, Yang, Hui, Zhou, Yingsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265090/
https://www.ncbi.nlm.nih.gov/pubmed/37098587
http://dx.doi.org/10.1002/advs.202206813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265090/
https://www.ncbi.nlm.nih.gov/pubmed/37098587
http://dx.doi.org/10.1002/advs.202206813

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