Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer

Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model. Unexpectedly, impairment of Phgdh enzyme activity exerts a slight effect in a liver cancer m...

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Detalles Bibliográficos
Autores principales: Zhu, Hongwen, Yu, Hua, Zhou, Hu, Zhu, Wencheng, Wang, Xiongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265107/
https://www.ncbi.nlm.nih.gov/pubmed/37078828
http://dx.doi.org/10.1002/advs.202205818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265107/
https://www.ncbi.nlm.nih.gov/pubmed/37078828
http://dx.doi.org/10.1002/advs.202205818

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