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CRISPR activation and interference as investigative tools in the cardiovascular system
CRISPR activation and interference (CRISPRa/i) technology offers the unprecedented possibility of achieving regulated gene expression both in vitro and in vivo. The DNA pairing specificity of a nuclease dead Cas9 (dCas9) is exploited to precisely target a transcriptional activator or repressor in pr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265131/ https://www.ncbi.nlm.nih.gov/pubmed/36563996 http://dx.doi.org/10.1016/j.biocel.2022.106348 |