Heterozygous OT‐I mice reveal that antigen‐specific CD8 (+) T cells shift from apoptotic to necrotic killers in the elderly

Numerous alterations in CD8(+) T cells contribute to impaired immune responses in elderly individuals. However, the discrimination between cell‐intrinsic dysfunctions and microenvironmental changes is challenging. TCR transgenic OT‐I mice are utilized to investigate CD8(+) T‐cell immunity, but their...

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Detalles Bibliográficos
Autores principales: Zöphel, Dorina, Kaschek, Lea, Steiner, Romy, Janku, Sandra, Chang, Hsin‐Fang, Lis, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265152/
https://www.ncbi.nlm.nih.gov/pubmed/36947105
http://dx.doi.org/10.1111/acel.13824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265152/
https://www.ncbi.nlm.nih.gov/pubmed/36947105
http://dx.doi.org/10.1111/acel.13824

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