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Heterozygous OT‐I mice reveal that antigen‐specific CD8 (+) T cells shift from apoptotic to necrotic killers in the elderly
Numerous alterations in CD8(+) T cells contribute to impaired immune responses in elderly individuals. However, the discrimination between cell‐intrinsic dysfunctions and microenvironmental changes is challenging. TCR transgenic OT‐I mice are utilized to investigate CD8(+) T‐cell immunity, but their...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265152/ https://www.ncbi.nlm.nih.gov/pubmed/36947105 http://dx.doi.org/10.1111/acel.13824 |