Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial DNA deletion mutations in human aging

Mitochondrial DNA (mtDNA) deletion mutations cause many human diseases and are linked to age‐induced mitochondrial dysfunction. Mapping the mutation spectrum and quantifying mtDNA deletion mutation frequency is challenging with next‐generation sequencing methods. We hypothesized that long‐read seque...

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Detalles Bibliográficos
Autores principales: Vandiver, Amy R., Hoang, Austin N., Herbst, Allen, Lee, Cathy C., Aiken, Judd M., McKenzie, Debbie, Teitell, Michael A., Timp, Winston, Wanagat, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265159/
https://www.ncbi.nlm.nih.gov/pubmed/37132288
http://dx.doi.org/10.1111/acel.13842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265159/
https://www.ncbi.nlm.nih.gov/pubmed/37132288
http://dx.doi.org/10.1111/acel.13842

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