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Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial DNA deletion mutations in human aging
Mitochondrial DNA (mtDNA) deletion mutations cause many human diseases and are linked to age‐induced mitochondrial dysfunction. Mapping the mutation spectrum and quantifying mtDNA deletion mutation frequency is challenging with next‐generation sequencing methods. We hypothesized that long‐read seque...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265159/ https://www.ncbi.nlm.nih.gov/pubmed/37132288 http://dx.doi.org/10.1111/acel.13842 |