Cargando…

Computational screen to identify potential targets for immunotherapeutic identification and removal of senescence cells

To prioritize gene and protein candidates that may enable the selective identification and removal of senescent cells, we compared gene expression signatures from replicative senescent cells to transcriptomics and proteomics atlases of normal human tissues and cell types. RNA‐seq samples from in vit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Eden Z., Fleishman, Reid H., Xie, Zhuorui, Marino, Giacomo B., Clarke, Daniel J. B., Ma'ayan, Avi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Short Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265163/ https://www.ncbi.nlm.nih.gov/pubmed/37082798 http://dx.doi.org/10.1111/acel.13809

Ejemplares similares

GeneRanger and TargetRanger: processed gene and protein expression levels across cells and tissues for target discovery
por: Marino, Giacomo B, et al.
Publicado: (2023)

Enrichr-KG: bridging enrichment analysis across multiple libraries
por: Evangelista, John Erol, et al.
Publicado: (2023)

Dex-Benchmark: datasets and code to evaluate algorithms for transcriptomics data analysis
por: Xie, Zhuorui, et al.
Publicado: (2023)

lncHUB2: aggregated and inferred knowledge about human and mouse lncRNAs
por: Marino, Giacomo B, et al.
Publicado: (2023)

DrugShot: querying biomedical search terms to retrieve prioritized lists of small molecules
por: Kropiwnicki, Eryk, et al.
Publicado: (2022)

Transforming L1000 profiles to RNA-seq-like profiles with deep learning
por: Jeon, Minji, et al.
Publicado: (2022)

Gene and drug landing page aggregator
por: Clarke, Daniel J B, et al.
Publicado: (2022)

KEA3: improved kinase enrichment analysis via data integration
por: Kuleshov, Maxim V, et al.
Publicado: (2021)

Complex systems biology
por: Ma'ayan, Avi
Publicado: (2017)

Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice
por: Shrestha, Niraj, et al.
Publicado: (2023)

Age alters the oncogenic trajectory toward luminal mammary tumors that activate unfolded proteins responses
por: Jenkins, Edmund Charles, et al.
Publicado: (2022)

Genes2WordCloud: a quick way to identify biological themes from gene lists and free text
por: Baroukh, Caroline, et al.
Publicado: (2011)

KEA: kinase enrichment analysis
por: Lachmann, Alexander, et al.
Publicado: (2009)

Lists2Networks: Integrated analysis of gene/protein lists
por: Lachmann, Alexander, et al.
Publicado: (2010)

An open RNA-Seq data analysis pipeline tutorial with an example of reprocessing data from a recent Zika virus study
por: Wang, Zichen, et al.
Publicado: (2016)

Toxicology knowledge graph for structural birth defects
por: Evangelista, John Erol, et al.
Publicado: (2023)

Sig2BioPAX: Java tool for converting flat files to BioPAX Level 3 format
por: Webb, Ryan L, et al.
Publicado: (2011)

A genomics approach identifies senescence-specific gene expression regulation
por: Lackner, Daniel H, et al.
Publicado: (2014)

SigCom LINCS: data and metadata search engine for a million gene expression signatures
por: Evangelista, John Erol, et al.
Publicado: (2022)

Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition
por: Koplev, Simon, et al.
Publicado: (2018)

PrismEXP: gene annotation prediction from stratified gene-gene co-expression matrices
por: Lachmann, Alexander, et al.
Publicado: (2023)

Mining data and metadata from the gene expression omnibus
por: Wang, Zichen, et al.
Publicado: (2018)

The characteristic direction: a geometrical approach to identify differentially expressed genes
por: Clark, Neil R, et al.
Publicado: (2014)

Cellular senescence affects energy metabolism, immune infiltration and immunotherapeutic response in hepatocellular carcinoma
por: Gao, Biao, et al.
Publicado: (2023)

Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients
por: Li, Zhuorui, et al.
Publicado: (2022)

SVM classifier to predict genes important for self-renewal and pluripotency of mouse embryonic stem cells
por: Xu, Huilei, et al.
Publicado: (2010)

Genes2FANs: connecting genes through functional association networks
por: Dannenfelser, Ruth, et al.
Publicado: (2012)

Dynamics of the discovery process of protein-protein interactions from low content studies
por: Wang, Zichen, et al.
Publicado: (2015)

Gene set predictor for post-treatment Lyme disease
por: Clarke, Daniel J.B., et al.
Publicado: (2022)

Identification and validation of cellular senescence patterns to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma
por: Lin, Weihao, et al.
Publicado: (2021)

Genes2Networks: connecting lists of gene symbols using mammalian protein interactions databases
por: Berger, Seth I, et al.
Publicado: (2007)

Histone H3.3 and its proteolytically processed form drive a cellular senescence program
por: Duarte, Luis F., et al.
Publicado: (2014)

Role of MicroRNAs in acceleration of vascular endothelial senescence
por: Toyama, Kensuke, et al.
Publicado: (2022)

Are skin senescence and immunosenescence linked within individuals?
por: Waaijer, Mariëtte E. C., et al.
Publicado: (2019)

Tumor Microenvironment Profiling Identifies Prognostic Signatures and Suggests Immunotherapeutic Benefits in Neuroblastoma
por: Feng, Chenzhao, et al.
Publicado: (2022)

Predicting opioid dependence from electronic health records with machine learning
por: Ellis, Randall J., et al.
Publicado: (2019)

MicroRNAs as novel immunotherapeutics
por: Heimberger, Amy B, et al.
Publicado: (2013)

Cascade screening for β-thalassemia: A practical approach for identifying and counseling carriers in India
por: Gorakshakar, Ajit C, et al.
Publicado: (2009)

Senescence chips for ultrahigh‐throughput isolation and removal of senescent cells
por: Chen, Yuchao, et al.
Publicado: (2018)

High-throughput chromatin screens to identify targets of senescence and aging
por: Sen, Payel
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_52ji4jpnp7snrm8b98h77shbsl