Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson‐Gilford progeria syndrome in mice

Partial cellular reprogramming via transient expression of Oct4, Sox2, Klf4, and c‐Myc induces rejuvenation and reduces aged‐cell phenotypes. In this study, we found that transcriptional activation of the endogenous Oct4 gene by using the CRISPR/dCas9 activator system can efficiently ameliorate hall...

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Detalles Bibliográficos
Autores principales: Kim, Junyeop, Hwang, Yerim, Kim, Sumin, Chang, Yujung, Kim, Yunkyung, Kwon, Youngeun, Kim, Jongpil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265166/
https://www.ncbi.nlm.nih.gov/pubmed/36964992
http://dx.doi.org/10.1111/acel.13825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265166/
https://www.ncbi.nlm.nih.gov/pubmed/36964992
http://dx.doi.org/10.1111/acel.13825

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