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The flavonoid fisetin ameliorates renal fibrosis by inhibiting SMAD3 phosphorylation, oxidative damage, and inflammation in ureteral obstructed kidney in mice

BACKGROUND: Renal fibrosis is characterized by the accumulation of extracellular matrix and inflammatory cells and kidney dysfunction, which is a major pathway in the progression of chronic kidney disease (CKD). Accumulating evidence indicates that oxidative stress plays a critical role in the initi...

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Detalles Bibliográficos
Autores principales: Ju, Ha Young, Kim, Jongwan, Han, Sang Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Nephrology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265205/
https://www.ncbi.nlm.nih.gov/pubmed/37098680
http://dx.doi.org/10.23876/j.krcp.22.034