A superoxide-driven redox state promotes geroconversion and resistance to senolysis in replication-stress associated senescence

Using S-phase synchronized RPE1-hTERT cells exposed to the DNA damaging agent, methyl methanesulfonate, we show the existence of a redox state associated with replication stress-induced senescence termed senescence-associated redox state (SA-redox state). SA-redox state is characterized by its react...

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Detalles Bibliográficos
Autores principales: Luo, Le, Pervaiz, Shazib, Clement, Marie-Veronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265521/
https://www.ncbi.nlm.nih.gov/pubmed/37285741
http://dx.doi.org/10.1016/j.redox.2023.102757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265521/
https://www.ncbi.nlm.nih.gov/pubmed/37285741
http://dx.doi.org/10.1016/j.redox.2023.102757

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