Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD(+) regeneration in KRas-mutant lung adenocarcinoma

Oncogenic KRas activates mitochondrial fission through Erk-mediated phosphorylation of the mitochondrial fission GTPase Drp1. Drp1 deletion inhibits tumorigenesis of KRas-driven pancreatic cancer, but the role of mitochondrial dynamics in other Ras-driven malignancies is poorly defined. Here we show...

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Detalles Bibliográficos
Autores principales: Sessions, Dane T., Kim, Kee-Beom, Kashatus, Jennifer A., Churchill, Nikolas, Park, Kwon-Sik, Mayo, Marty W., Sesaki, Hiromi, Kashatus, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265649/
https://www.ncbi.nlm.nih.gov/pubmed/36516772
http://dx.doi.org/10.1016/j.celrep.2022.111818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265649/
https://www.ncbi.nlm.nih.gov/pubmed/36516772
http://dx.doi.org/10.1016/j.celrep.2022.111818

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