Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration
BACKGROUND: Age-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the leading cause of irreversible vision impairment among the elderly. RPE senescence is an important contributor to AMD and has become a potential target...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265780/ https://www.ncbi.nlm.nih.gov/pubmed/37316948 http://dx.doi.org/10.1186/s12964-023-01138-9 |