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The tumor promoter cysteinyl leukotriene receptor 1 regulates PD-L1 expression in colon cancer cells via the Wnt/β-catenin signaling axis

Immunotherapy targeting programmed death-ligand 1 (PD-L1) or PD-1 in solid tumors has been shown to be clinically beneficial. However, in colorectal cancer (CRC), only a subset of patients benefit from PD-1/PD-L1 treatment. Previously, we showed that high cysteinyl leukotriene receptor 1 (CysLT(1)R)...

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Detalles Bibliográficos
Autores principales: Satapathy, Shakti Ranjan, Ghatak, Souvik, Sjölander, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265834/
https://www.ncbi.nlm.nih.gov/pubmed/37316937
http://dx.doi.org/10.1186/s12964-023-01157-6