Cargando…

Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy

BACKGROUND: Most patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these cancers is generally immunosuppressive and contains few tumor-infiltrating lymphocytes. Radiation therapy (RT) can increase tu...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Leary, Kathleen A., Bates, Amber M., Jin, Won Jong, Burkel, Brian M., Sriramaneni, Raghava N., Emma, Sarah E., Nystuen, Erin J., Sumiec, Elizabeth G., Ponik, Suzanne M., Morris, Zachary S., Schuler, Linda A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265911/ https://www.ncbi.nlm.nih.gov/pubmed/37312163 http://dx.doi.org/10.1186/s13058-023-01671-y

Ejemplares similares

Dynamic interactions between the extracellular matrix and estrogen activity in progression of ER+ breast cancer
por: Jallow, Fatou, et al.
Publicado: (2019)

Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization
por: Jagodinsky, Justin C, et al.
Publicado: (2022)

Tumor-Specific Antibody, Cetuximab, Enhances the In Situ Vaccine Effect of Radiation in Immunologically Cold Head and Neck Squamous Cell Carcinoma
por: Jin, Won Jong, et al.
Publicado: (2020)

Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade
por: Zhang, Ying, et al.
Publicado: (2022)

In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response
por: Baniel, Claire C., et al.
Publicado: (2020)

Endogenous and Therapeutic Estrogens: Maestro Conductors of the Microenvironment of ER+ Breast Cancers
por: Schuler, Linda A., et al.
Publicado: (2021)

Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells
por: Vydra, Natalia, et al.
Publicado: (2021)

Intralesional administration of VAX014 facilitates in situ immunization and potentiates immune checkpoint blockade in immunologically cold tumors
por: Reil, Katherine A, et al.
Publicado: (2023)

Relaxin-expressing oncolytic adenovirus induces remodeling of physical and immunological aspects of cold tumor to potentiate PD-1 blockade
por: Jung, Bo-Kyeong, et al.
Publicado: (2020)

Combination of Bempegaldesleukin and Anti-CTLA-4 Prevents Metastatic Dissemination After Primary Resection or Radiotherapy in a Preclinical Model of Non-Small Cell Lung Cancer
por: Bates, Amber M., et al.
Publicado: (2021)

Immunological modulation of estrogen during sepsis
por: Stabile, AM, et al.
Publicado: (2012)

Targeting estrogen to kill ER-positive and ER-negative breast cancer
por: Jordan, VC
Publicado: (2005)

PMON14 Estrogen Activity of Supplements Targeted for Post-Menopausal Women
por: O’Leary, Emily, et al.
Publicado: (2022)

Blockade of Estrogen Action Upregulates Estrogen Receptor-α mRNA in the Fetal Brain
por: Schaub, Christine E., et al.
Publicado: (2009)

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells
por: Morris, Brett A., et al.
Publicado: (2016)

Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER
por: Girgert, Rainer, et al.
Publicado: (2019)

HER2 and ERβ2 downregulate estrogen-responsive element-mediated transcription activity of ERα-positive cells in response to estrogen stimulation
por: Park, B-W, et al.
Publicado: (2005)

Functions and physiological roles of two types of estrogen receptors, ERα and ERβ, identified by estrogen receptor knockout mouse
por: Lee, Hye-Rim, et al.
Publicado: (2012)

A role for estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in collagen biosynthesis in mouse skin
por: Markiewicz, Margaret, et al.
Publicado: (2012)

Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy
por: Jagodinsky, Justin C., et al.
Publicado: (2021)

IMMUNOLOGICAL ADJUVANTS AND THE MECHANISM OF CELL COOPERATION
por: Maillard, Jean, et al.
Publicado: (1972)

Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice
por: Knowlton, Wendy M., et al.
Publicado: (2011)

Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα
por: Alonso-Magdalena, Paloma, et al.
Publicado: (2008)

The Co-Expression of Estrogen Receptors ERα, ERβ, and GPER in Endometrial Cancer
por: Hojnik, Marko, et al.
Publicado: (2023)

The Immunological Epigenetic Landscape of the Human Life Trajectory
por: Juříčková, Iva, et al.
Publicado: (2022)

ERα expression in T lymphocytes is dispensable for estrogenic effects in bone
por: Gustafsson, K L, et al.
Publicado: (2018)

Radiation Augments the Local Anti-Tumor Effect of In Situ Vaccine With CpG-Oligodeoxynucleotides and Anti-OX40 in Immunologically Cold Tumor Models
por: Pieper, Alexander A., et al.
Publicado: (2021)

Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model
por: Baniel, Claire C, et al.
Publicado: (2020)

Fermilab: Transatlantic cooperation on cold detectors
Publicado: (1981)

A tale of two estrogen receptors (ERs): how differential ER-estrogen responsive element interactions contribute to subtype-specific transcriptional responses
por: Huang, Jing, et al.
Publicado: (2006)

Targeted Protein Destabilization Reveals an Estrogen-mediated ER Stress Response
por: Raina, Kanak, et al.
Publicado: (2014)

The immunologic effects of estrogen on psoriasis: A comprehensive review()()
por: Danesh, Melissa, et al.
Publicado: (2015)

Clinical trials proposed for the VA Cooperative Studies Program: Success rates and factors impacting approval()
por: Burnaska, David R., et al.
Publicado: (2021)

Therapeutic strategies to remodel immunologically cold tumors
por: Wang, Minyu, et al.
Publicado: (2020)

Prolactin: The Third Hormone in Breast Cancer
por: Schuler, Linda A., et al.
Publicado: (2022)

Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens
por: Gong, Ping, et al.
Publicado: (2014)

Estrogens and Progestins Cooperatively Shift Breast Cancer Cell Metabolism
por: Ward, Ashley V., et al.
Publicado: (2022)

The Possible Impact of Obesity on Androgen, Progesterone and Estrogen Receptors (ERα and ERβ) Gene Expression in Breast Cancer Patients
por: Esfahlan, R. Jahanban, et al.
Publicado: (2011)

Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism
por: Dunlap, Tareisha L., et al.
Publicado: (2017)

Cooperating transcription factors mediate the function of estrogen receptor
por: Fiorito, Elisa, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_db0fjs1f648tr3p6lsefkfbqbd