Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function

Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is located in the cTnT N-terminal (TnT1) loop region and is known for its pathological and prognostic relevance. A recent structura...

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Detalles Bibliográficos
Autores principales: Landim-Vieira, Maicon, Ma, Weikang, Song, Taejeong, Rastegarpouyani, Hosna, Gong, Henry, Coscarella, Isabella Leite, Bogaards, Sylvia J. P., Conijn, Stefan P., Ottenheijm, Coen A. C., Hwang, Hyun S., Papadaki, Maria, Knollmann, Bjorn C., Sadayappan, Sakthivel, Irving, Thomas C., Galkin, Vitold E., Chase, P. Bryant, Pinto, Jose Renato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265946/
https://www.ncbi.nlm.nih.gov/pubmed/37252999
http://dx.doi.org/10.1073/pnas.2221244120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265946/
https://www.ncbi.nlm.nih.gov/pubmed/37252999
http://dx.doi.org/10.1073/pnas.2221244120

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