PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers

The chromatin-modifying enzyme, Polycomb Repressive Complex 2 (PRC2), deposits the H3K27me3 epigenetic mark to negatively regulate expression at numerous target genes, and this activity has been implicated in embryonic development, cell differentiation, and various cancers. A biological role for RNA...

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Detalles Bibliográficos
Autores principales: Hemphill, Wayne O., Fenske, Regan, Gooding, Anne R., Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266057/
https://www.ncbi.nlm.nih.gov/pubmed/37252986
http://dx.doi.org/10.1073/pnas.2220528120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266057/
https://www.ncbi.nlm.nih.gov/pubmed/37252986
http://dx.doi.org/10.1073/pnas.2220528120

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