ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM

AlkB homolog 5, RNA demethylase (ALKBH5) is abnormally highly expressed in glioblastoma multiforme (GBM) and is negatively correlated with overall survival in GBM patients. In this study, we found a new mechanism that ALKBH5 and pyrroline-5-carboxylate reductase 2 (PYCR2) formed a positive feedback...

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Detalles Bibliográficos
Autores principales: Li, Li, Yang, Mengting, Pu, Xufeng, Tang, Yu, Fei, Fei, Li, Zhangzuo, Hou, Hanjin, Chen, Qian, Wang, Qiaowei, Wu, Yuqing, Zhang, Ying, Ren, Caifang, Gong, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266253/
https://www.ncbi.nlm.nih.gov/pubmed/37325047
http://dx.doi.org/10.7150/jca.84213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266253/
https://www.ncbi.nlm.nih.gov/pubmed/37325047
http://dx.doi.org/10.7150/jca.84213

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