Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis

INTRODUCTION: Osteopontin (OPN; also known as SPP1), an immunomodulatory cytokine highly expressed in bone marrow-derived macrophages (BMMΦ), is known to regulate diverse cellular and molecular immune responses. We previously revealed that glatiramer acetate (GA) stimulation of BMMΦ upregulates OPN...

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Detalles Bibliográficos
Autores principales: Rentsendorj, Altan, Raedschelders, Koen, Fuchs, Dieu-Trang, Sheyn, Julia, Vaibhav, Vineet, Porritt, Rebecca A., Shi, Haoshen, Dagvadorj, Jargalsaikhan, de Freitas Germano, Juliana, Koronyo, Yosef, Arditi, Moshe, Black, Keith L., Gaire, Bhakta Prasad, Van Eyk, Jennifer E., Koronyo-Hamaoui, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266348/
https://www.ncbi.nlm.nih.gov/pubmed/37325640
http://dx.doi.org/10.3389/fimmu.2023.1155935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266348/
https://www.ncbi.nlm.nih.gov/pubmed/37325640
http://dx.doi.org/10.3389/fimmu.2023.1155935

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