Minimizing the off-target frequency of the CRISPR/Cas9 system via zwitterionic polymer conjugation and peptide fusion

The clustered, regularly interspaced, short palindromic repeats (CRISPR)–associated protein 9 (Cas9) system is a powerful genome-editing tool that is widely used in many different applications. However, the high-frequency mutations induced by RNA-guided Cas9 at sites other than the intended on-targe...

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Detalles Bibliográficos
Autores principales: Han, Yanjiao, Yuan, Zhefan, Zhong, Sijin Luo, Xu, Haoxian, Jiang, Shaoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266473/
https://www.ncbi.nlm.nih.gov/pubmed/37325144
http://dx.doi.org/10.1039/d2sc07067g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266473/
https://www.ncbi.nlm.nih.gov/pubmed/37325144
http://dx.doi.org/10.1039/d2sc07067g

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