A sustainable, efficient, and potentially cost-effective approach to the antimalarial drug candidate MMV688533

A 6-step synthesis of the antimalarial drug candidate MMV688533 is reported. Key transformations carried out under aqueous micellar conditions include two Sonogashira couplings and amide bond formation. Compared with the first-generation manufacturing process reported by Sanofi, the current route fe...

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Detalles Bibliográficos
Autores principales: Kavthe, Rahul D., Iyer, Karthik S., Caravez, Juan C., Lipshutz, Bruce H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266478/
https://www.ncbi.nlm.nih.gov/pubmed/37325157
http://dx.doi.org/10.1039/d3sc01699d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266478/
https://www.ncbi.nlm.nih.gov/pubmed/37325157
http://dx.doi.org/10.1039/d3sc01699d

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