Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor

Bortezomib has been successful for treatment of multiple myeloma, but not against solid tumors, and toxicities of neuropathy, thrombocytopenia and the emergence of resistance have triggered efforts to find alternative proteasome inhibitors. Bis-benzylidine piperidones such as RA190 covalently bind A...

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Detalles Bibliográficos
Autores principales: Anchoori, Ravi K., Anchoori, Vidyasagar, Lam, Brandon, Tseng, Ssu-Hsueh, Das, Samarjit, Velasquez, Fernanda Carrizo, Karanam, Balasubramanyam, Poddatoori, Deepika, Patnam, Ramesh, Rudek, Michelle A., Chang, Yung-Nien, Roden, Richard B. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266688/
https://www.ncbi.nlm.nih.gov/pubmed/37315065
http://dx.doi.org/10.1371/journal.pone.0285221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266688/
https://www.ncbi.nlm.nih.gov/pubmed/37315065
http://dx.doi.org/10.1371/journal.pone.0285221

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