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Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor
Bortezomib has been successful for treatment of multiple myeloma, but not against solid tumors, and toxicities of neuropathy, thrombocytopenia and the emergence of resistance have triggered efforts to find alternative proteasome inhibitors. Bis-benzylidine piperidones such as RA190 covalently bind A...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266688/ https://www.ncbi.nlm.nih.gov/pubmed/37315065 http://dx.doi.org/10.1371/journal.pone.0285221 |