Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation

While defective α-synuclein homeostasis is central to Parkinson’s pathogenesis, fundamental questions about its degradation remain unresolved. We have developed a bimolecular fluorescence complementation assay in living cells to monitor de novo ubiquitination of α-synuclein and identified lysine res...

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Detalles Bibliográficos
Autores principales: Zenko, Dmitry, Marsh, Jade, Castle, Andrew R., Lewin, Rahel, Fischer, Roman, Tofaris, George K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266730/
https://www.ncbi.nlm.nih.gov/pubmed/37315142
http://dx.doi.org/10.1126/sciadv.add8910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266730/
https://www.ncbi.nlm.nih.gov/pubmed/37315142
http://dx.doi.org/10.1126/sciadv.add8910

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