Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage

Acute hemorrhage commonly leads to coagulopathy and organ dysfunction or failure. Recent evidence suggests that damage to the endothelial glycocalyx contributes to these adverse outcomes. The physiological events mediating acute glycocalyx shedding are undefined, however. Here, we show that succinat...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdullah, Sarah, Ghio, Michael, Cotton-Betteridge, Aaron, Vinjamuri, Aditya, Drury, Robert, Packer, Jacob, Aras, Oguz, Friedman, Jessica, Karim, Mardeen, Engelhardt, David, Kosowski, Emma, Duong, Kelby, Shaheen, Farhana, McGrew, Patrick R., Harris, Charles T., Reily, Robert, Sammarco, Mimi, Chandra, Partha K., Pociask, Derek, Kolls, Jay, Katakam, Prasad V., Smith, Alison, Taghavi, Sharven, Duchesne, Juan, Jackson-Weaver, Olan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266735/
https://www.ncbi.nlm.nih.gov/pubmed/37315138
http://dx.doi.org/10.1126/sciadv.adf6600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266735/
https://www.ncbi.nlm.nih.gov/pubmed/37315138
http://dx.doi.org/10.1126/sciadv.adf6600

Ejemplares similares