Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies

Palmitoylation is a critical posttranslational modification that enables the cellular membrane localization and subsequent activation of RAS proteins, including HRAS, KRAS, and NRAS. However, the molecular mechanism that regulates RAS palmitoylation in malignant diseases remains unclear. In this iss...

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Detalles Bibliográficos
Autores principales: Yu, Fang, Qian, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266771/
https://www.ncbi.nlm.nih.gov/pubmed/37317974
http://dx.doi.org/10.1172/JCI171104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266771/
https://www.ncbi.nlm.nih.gov/pubmed/37317974
http://dx.doi.org/10.1172/JCI171104

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