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Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies
Palmitoylation is a critical posttranslational modification that enables the cellular membrane localization and subsequent activation of RAS proteins, including HRAS, KRAS, and NRAS. However, the molecular mechanism that regulates RAS palmitoylation in malignant diseases remains unclear. In this iss...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Clinical Investigation
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266771/ https://www.ncbi.nlm.nih.gov/pubmed/37317974 http://dx.doi.org/10.1172/JCI171104 |