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Negativity begets longevity in T cells

Killer immunoglobulin-like receptors (KIRs) are polymorphic receptors for human leukocyte antigens (HLAs) that provide positive or negative signals controlling lymphocyte activation. Expression of inhibitory KIRs by CD8(+) T cells affects their survival and function, which is linked to improved anti...

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Detalles Bibliográficos
Autores principales: Feldman, H. Alex, Cevik, Hilal, Waggoner, Stephen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266772/
https://www.ncbi.nlm.nih.gov/pubmed/37317967
http://dx.doi.org/10.1172/JCI171027