Basement membrane proteins in extracellular matrix characterize NF1 neurofibroma development and response to MEK inhibitor

Neurofibromatosis type 1 (NF1) is one of the most common tumor-predisposing genetic disorders. Neurofibromas are NF1-associated benign tumors. A hallmark feature of neurofibromas is an abundant collagen-rich extracellular matrix (ECM) that constitutes more than 50% of the tumor dry weight. However,...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Chunhui, Kumar, Ashwani, Yu, Ze, Shipman, Tracey, Wang, Yong, McKay, Renee M., Xing, Chao, Le, Lu Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266775/
https://www.ncbi.nlm.nih.gov/pubmed/37140985
http://dx.doi.org/10.1172/JCI168227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266775/
https://www.ncbi.nlm.nih.gov/pubmed/37140985
http://dx.doi.org/10.1172/JCI168227

Ejemplares similares