Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology

Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain. Using a knockin mouse line in which a Td-tomato reporter is incorporated into the endogenous C3ar1 locus, we identified 2 major subpopulations of microglia with differential C3aR expression. Expressing the Td-t...

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Detalles Bibliográficos
Autores principales: Gedam, Manasee, Comerota, Michele M., Propson, Nicholas E., Chen, Tao, Jin, Feng, Wang, Meng C., Zheng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266793/
https://www.ncbi.nlm.nih.gov/pubmed/37317973
http://dx.doi.org/10.1172/JCI167501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266793/
https://www.ncbi.nlm.nih.gov/pubmed/37317973
http://dx.doi.org/10.1172/JCI167501

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