Structure guided studies of the interaction between PTP1B and JAK

Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated substrates. Here we identify PTP1B as an inhibitor of IL-6 and show t...

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Detalles Bibliográficos
Autores principales: Morris, Rhiannon, Keating, Narelle, Tan, Cyrus, Chen, Hao, Laktyushin, Artem, Saiyed, Tamanna, Liau, Nicholas P. D., Nicola, Nicos A., Tiganis, Tony, Kershaw, Nadia J., Babon, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267100/
https://www.ncbi.nlm.nih.gov/pubmed/37316570
http://dx.doi.org/10.1038/s42003-023-05020-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267100/
https://www.ncbi.nlm.nih.gov/pubmed/37316570
http://dx.doi.org/10.1038/s42003-023-05020-9

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